Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | STS | P08842 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
| ▸ | PTPRB | P23467 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30750572 | 0.98 | JAK2 (0.49) | JAK2JAK1STSGPR119KDM4E | |
| SCHEMBL27379853 | 0.97 | JAK2 (0.52) | JAK2JAK1STSGPR119KDM4E | |
| SCHEMBL27380148 | 0.96 | JAK2 (0.51) | JAK2JAK1STSGPR119KDM4E | |
| SCHEMBL30750672 | 0.95 | JAK2 (0.48) | JAK2JAK1STSGPR119KDM4E | |
| SCHEMBL30750662 | 0.95 | JAK2 (0.50) | JAK2JAK1STSGPR119KDM4E | |
| SCHEMBL20133355 | 0.86 | STS (0.51) | JAK2JAK1STSGPR119KDM4E | |
| SCHEMBL30750608 | 0.85 | STS (0.50) | JAK2JAK1STSGPR119KDM4E | |
| SCHEMBL13096781 | 0.85 | STS (0.52) | JAK2JAK1STSGPR119KDM4E | |
| SCHEMBL30812219 | 0.83 | JAK2 (0.55) | JAK2JAK1STSGPR119KDM4E | |
| SCHEMBL31303428 | 0.83 | STS (0.52) | JAK2JAK1STSGPR119KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054954-A1 | HETEROBIFUNCTIONAL COMPOUNDS AND METHODS OF TREATING DISEASE | HALDA THERAPEUTICS OPCO, INC. (US) | 2024-03-14 | — | — | WO | disclosed |