Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 4/20 | 0.65 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.65 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.48 |
| ▸ | EDNRB | P24530 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 5/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26688750 | 1.00 | EDNRA (0.65) | EDNRAAGTR1AGTR2EDNRBACHE | |
| SCHEMBL5527092 | 0.86 | EDNRA (0.70) | EDNRAAGTR1AGTR2EDNRBACHE | |
| SCHEMBL5529443 | 0.85 | EDNRA (0.69) | EDNRAAGTR1AGTR2EDNRBACHE | |
| SCHEMBL30757466 | 0.84 | EDNRA (0.48) | EDNRAAGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL26688857 | 0.84 | EDNRA (0.48) | EDNRAAGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL4772943 | 0.84 | EDNRA (0.79) | EDNRAAGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL6539684 | 0.83 | EDNRA (0.89) | EDNRAAGTR1AGTR2EDNRBACHE | |
| SCHEMBL27418899 | 0.82 | EDNRA (0.74) | EDNRAAGTR1AGTR2EDNRBACHE | |
| SCHEMBL29706543 | 0.82 | EDNRA (0.87) | EDNRAAGTR1AGTR2EDNRBACHE | |
| SCHEMBL5791243 | 0.82 | EDNRA (0.87) | EDNRAAGTR1AGTR2EDNRBACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023224963-A1 | DUAL-ACTING ANGIOTENSIN AND ENDOTHELIN RECEPTOR ANTAGONISTS | ARIA PHARMACEUTICALS, INC. (US) | 2023-11-23 | — | — | WO | disclosed |