Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 11/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.38 |
| ▸ | EDNRB | P24530 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26688926 | 1.00 | EDNRA (0.43) | EDNRAAGTR1EDNRBTP53MAPT | |
| SCHEMBL5531005 | 0.91 | EDNRA (0.41) | EDNRAAGTR1EDNRB | |
| SCHEMBL30757307 | 0.90 | EDNRA (0.44) | EDNRAAGTR1EDNRB | |
| SCHEMBL26688742 | 0.90 | EDNRA (0.44) | EDNRAAGTR1EDNRB | |
| SCHEMBL26688907 | 0.90 | EDNRA (0.42) | EDNRAAGTR1EDNRBTP53MAPT | |
| SCHEMBL30757434 | 0.90 | EDNRA (0.42) | EDNRAAGTR1EDNRBTP53MAPT | |
| SCHEMBL31366164 | 0.90 | EDNRA (0.42) | EDNRAAGTR1EDNRBTP53MAPT | |
| SCHEMBL5531007 | 0.90 | EDNRA (0.41) | EDNRAAGTR1EDNRB | |
| SCHEMBL4764404 | 0.86 | EDNRA (0.41) | EDNRAAGTR1 | |
| SCHEMBL5531220 | 0.85 | EDNRA (0.37) | EDNRAAGTR1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023224963-A1 | DUAL-ACTING ANGIOTENSIN AND ENDOTHELIN RECEPTOR ANTAGONISTS | ARIA PHARMACEUTICALS, INC. (US) | 2023-11-23 | — | — | WO | disclosed |