Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.84 |
| ▸ | SYK | P43405 | 13/20 | 0.78 |
| ▸ | JAK1 | P23458 | 1/20 | 0.78 |
| ▸ | TYK2 | P29597 | 1/20 | 0.78 |
| ▸ | JAK3 | P52333 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14717503 | 1.00 | JAK2 (0.84) | JAK2SYKJAK1TYK2JAK3 | |
| SCHEMBL20376706 | 0.92 | JAK2 (0.86) | JAK2SYKJAK1TYK2JAK3 | |
| SCHEMBL14716846 | 0.91 | JAK2 (1.00) | JAK2SYKJAK1TYK2JAK3 | |
| SCHEMBL22101952 | 0.90 | SYK (0.93) | JAK2SYKJAK1TYK2JAK3 | |
| SCHEMBL14717727 | 0.90 | SYK (0.83) | JAK2SYKJAK1TYK2JAK3 | |
| SCHEMBL14716649 | 0.89 | JAK2 (1.00) | JAK2SYKJAK1TYK2JAK3 | |
| SCHEMBL14716981 | 0.89 | JAK2 (0.83) | JAK2SYKJAK1TYK2JAK3 | |
| SCHEMBL14717352 | 0.89 | JAK2 (1.00) | JAK2SYKJAK1TYK2JAK3 | |
| SCHEMBL30604964 | 0.89 | JAK2 (0.83) | JAK2SYKJAK1TYK2JAK3 | |
| SCHEMBL14717482 | 0.88 | JAK2 (1.00) | JAK2SYKJAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4327886-A2 | PYRIMIDO- PYRIDAZINONE COMPOUNDS AND USE THEREOF | Libertas Bio, Inc. (US) | 2024-02-28 | — | — | EP | disclosed |