SCHEMBL30758149

SCHEMBL30758149

Cc1nc2c(F)cc(-c3nc(Cl)ncc3Cl)cc2c(C)c1C(C)O

nearest known ligand 0.35

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CCND3 P30281 19/20 0.35
CDK6 Q00534 19/20 0.35
CDK4 P11802 18/20 0.35
CCND1 P24385 18/20 0.35
TNF P01375 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24619105 0.81 CCND3 (0.36) CCND3CDK6CDK4CCND1TNF
SCHEMBL31255091 0.77 CCND3 (0.34) CCND3CDK6CDK4CCND1TNF
SCHEMBL31413736 0.76 CCND3 (0.36) CCND3CDK6CDK4CCND1TNF
SCHEMBL30758216 0.75 TNF (0.39) CCND3CDK6CDK4CCND1TNF
SCHEMBL31373118 0.74 TNF (0.35) CCND3CDK6CDK4CCND1TNF
SCHEMBL26632763 0.73 TNF (0.41) CCND3CDK6CDK4CCND1TNF
SCHEMBL30629504 0.73 TNF (0.41) CCND3CDK6CDK4CCND1TNF
SCHEMBL24619122 0.72 CDK4 (0.31) CCND3CDK6CDK4CCND1TNF
SCHEMBL21522723 0.72 CDK4 (0.61) CCND3CDK6CDK4CCND1
SCHEMBL21522760 0.72 CDK4 (0.61) CCND3CDK6CDK4CCND1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4562000-A1 AMINOHETEROARYL KINASE INHIBITORS Allorion Therapeutics Inc (US) 2025-06-04 EP disclosed
CN-119630652-A Amino heteroaryl kinase inhibitors 安锐生物医药公司 2025-03-14 CN disclosed
WO-2024022487-A1 AMINOHETEROARYL KINASE INHIBITORS Allorion Therapeutics Inc (US) 2024-02-01 WO disclosed