Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | CTSD | P07339 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | CTSB | P07858 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25081013 | 1.00 | USP2 (0.52) | USP2SMN1; SMN2RECQLCTSDCTSL | |
| SCHEMBL26079201 | 0.83 | USP2 (0.56) | USP2SMN1; SMN2RECQLESR2NR1H2 | |
| SCHEMBL14954612 | 0.82 | ESR2 (0.46) | USP2SMN1; SMN2ESR2CTSKNR1H2 | |
| SCHEMBL2558056 | 0.82 | ESR2 (0.46) | USP2SMN1; SMN2ESR2CTSKNR1H2 | |
| SCHEMBL30803371 | 0.82 | ESR2 (0.46) | USP2SMN1; SMN2ESR2CTSKNR1H2 | |
| SCHEMBL344121 | 0.82 | USP2 (0.41) | USP2SMN1; SMN2ESR2CTSKNR1H2 | |
| SCHEMBL19331872 | 0.80 | MEN1 (0.42) | USP2SMN1; SMN2ESR2CTSKNR1H2 | |
| SCHEMBL21044819 | 0.80 | MEN1 (0.42) | USP2SMN1; SMN2ESR2CTSKNR1H2 | |
| SCHEMBL19331833 | 0.80 | MEN1 (0.42) | USP2SMN1; SMN2ESR2CTSKNR1H2 | |
| SCHEMBL1442351 | 0.78 | SMN1; SMN2 (0.61) | USP2SMN1; SMN2RECQLESR2NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4622716-A1 | SPIROCYCLIC DIHYDROPYRANOPYRIMIDINE KRAS INHIBITORS | Treeline Biosciences, Inc. (US) | 2025-10-01 | — | — | EP | disclosed |
| EP-4573095-A1 | PYRIDOPYRIMIDINE KRAS INHIBITORS | Treeline Biosciences, Inc. (US) | 2025-06-25 | — | — | EP | disclosed |
| WO-2024112654-A1 | SPIROCYCLIC DIHYDROPYRANOPYRIMIDINE KRAS INHIBITORS | Treeline Biosciences, Inc. (US) | 2024-05-30 | — | — | WO | disclosed |
| WO-2024040131-A1 | PYRIDOPYRIMIDINE KRAS INHIBITORS | Treeline Biosciences, Inc. (US) | 2024-02-22 | — | — | WO | disclosed |