Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | PTPRB | P23467 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30760937 | 1.00 | JAK2 (0.45) | JAK2JAK1BTKSRCEGFR | |
| SCHEMBL30760904 | 1.00 | JAK2 (0.45) | JAK2JAK1BTKSRCEGFR | |
| SCHEMBL30760877 | 1.00 | JAK2 (0.45) | JAK2JAK1BTKSRCEGFR | |
| SCHEMBL15710701 | 0.88 | BTK (0.57) | JAK2JAK1BTKSRCEGFR | |
| SCHEMBL15143899 | 0.88 | BTK (0.57) | JAK2JAK1BTKSRCEGFR | |
| SCHEMBL30760781 | 0.88 | JAK2 (0.43) | JAK2JAK1BTKSRCEGFR | |
| SCHEMBL30760807 | 0.88 | JAK2 (0.43) | JAK2JAK1BTKSRCEGFR | |
| SCHEMBL30760825 | 0.88 | JAK2 (0.43) | JAK2JAK1BTKSRCEGFR | |
| SCHEMBL30760857 | 0.88 | JAK2 (0.43) | JAK2JAK1BTKSRCEGFR | |
| SCHEMBL16320728 | 0.85 | BTK (0.51) | JAK2JAK1BTKSRCEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024037527-A1 | BTK DEGRADING COMPOUNDS | BEIJING NEOX BIOTECH LIMITED (CN) | 2024-02-22 | — | — | WO | disclosed |