Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 18/20 | 0.82 |
| ▸ | INSR | P06213 | 11/20 | 0.82 |
| ▸ | IGF1R | P08069 | 11/20 | 0.82 |
| ▸ | AURKA | O14965 | 2/20 | 0.70 |
| ▸ | ROS1 | P08922 | 2/20 | 0.70 |
| ▸ | EML4 | Q9HC35 | 2/20 | 0.70 |
| ▸ | EGFR | P00533 | 4/20 | 0.69 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.68 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.68 |
| ▸ | JAK2 | O60674 | 1/20 | 0.68 |
| ▸ | STK10 | O94804 | 1/20 | 0.68 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.68 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.68 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.68 |
| ▸ | ABL1 | P00519 | 1/20 | 0.68 |
| ▸ | CD74 | P04233 | 1/20 | 0.68 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.68 |
| ▸ | LCK | P06239 | 1/20 | 0.68 |
| ▸ | FYN | P06241 | 1/20 | 0.68 |
| ▸ | FES | P07332 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24207615 | 0.93 | ALK (0.73) | ALKINSRIGF1RAURKAROS1 | |
| SCHEMBL11916533 | 0.90 | ALK (1.00) | ALKINSRIGF1RAURKAROS1 | |
| SCHEMBL21847010 | 0.89 | ALK (0.81) | ALKINSRIGF1REGFR | |
| SCHEMBL11916601 | 0.89 | ALK (0.85) | ALKINSRIGF1RAURKAROS1 | |
| SCHEMBL22493310 | 0.88 | ALK (0.83) | ALKINSRIGF1RAURKAROS1 | |
| SCHEMBL16752969 | 0.88 | ALK (1.00) | ALK | |
| SCHEMBL16752955 | 0.88 | ALK (1.00) | ALK | |
| SCHEMBL11916443 | 0.87 | ALK (1.00) | ALKINSRIGF1RAURKAROS1 | |
| SCHEMBL22493315 | 0.87 | ALK (0.79) | ALKINSRIGF1RAURKAROS1 | |
| SCHEMBL16752912 | 0.86 | ALK (0.85) | ALKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024059525-A2 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANAPLASTIC LYMPHOMA KINASE AND ROS1 KINASE | ENDOTARGET, INC. (US) | 2024-03-21 | — | — | WO | disclosed |