Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.62 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.62 |
| ▸ | SRC | P12931 | 1/20 | 0.62 |
| ▸ | DDX6 | P26196 | 1/20 | 0.62 |
| ▸ | PDE4A | P27815 | 1/20 | 0.62 |
| ▸ | CSK | P41240 | 1/20 | 0.62 |
| ▸ | MTOR | P42345 | 1/20 | 0.62 |
| ▸ | PLK1 | P53350 | 1/20 | 0.62 |
| ▸ | PRKDC | P78527 | 1/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.62 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.62 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.62 |
| ▸ | AKT1 | P31749 | 8/20 | 0.60 |
| ▸ | AKT2 | P31751 | 8/20 | 0.60 |
| ▸ | AKT3 | Q9Y243 | 8/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30762609 | 0.92 | PIK3CA (0.52) | PIK3CAPIK3CBPIK3CDPIK3CGSRC | |
| SCHEMBL30762607 | 0.86 | PIK3CA (0.62) | PIK3CAPIK3CBPIK3CDPIK3CGSRC | |
| SCHEMBL30762397 | 0.86 | PIK3CA (0.62) | PIK3CAPIK3CBPIK3CDPIK3CGSRC | |
| SCHEMBL26137376 | 0.85 | AKT1 (0.63) | PIK3CAPIK3CBPIK3CDPIK3CGSRC | |
| SCHEMBL26137375 | 0.85 | AKT1 (0.63) | PIK3CAPIK3CBPIK3CDPIK3CGSRC | |
| SCHEMBL30762492 | 0.84 | AKT1 (0.62) | PIK3CAPIK3CBPIK3CDPIK3CGSRC | |
| SCHEMBL30762599 | 0.84 | AKT1 (0.62) | PIK3CAPIK3CBPIK3CDPIK3CGSRC | |
| SCHEMBL30762499 | 0.83 | AKT1 (0.61) | PIK3CAPIK3CBPIK3CDPIK3CGSRC | |
| SCHEMBL30808161 | 0.82 | PIK3CA (0.64) | PIK3CAPIK3CBPIK3CDPIK3CGSRC | |
| SCHEMBL30808153 | 0.82 | PIK3CA (0.64) | PIK3CAPIK3CBPIK3CDPIK3CGSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024026423-A1 | SUBSTITUTED QUINOLINE DERIVATIVES AS PI3K INHIBITORS | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2024-02-01 | — | — | WO | disclosed |