Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 9/20 | 0.60 |
| ▸ | HRH1 | P35367 | 1/20 | 0.60 |
| ▸ | KHK | P50053 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21686870 | 1.00 | HRH4 (0.60) | HRH4HRH1KHKALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL23855480 | 0.99 | HRH4 (0.59) | HRH4HRH1KHKALDH1A1CYP1A2 | |
| SCHEMBL21686826 | 0.89 | HRH4 (0.75) | HRH4HRH1HTR3ABRD4PDE5A | |
| SCHEMBL30763423 | 0.89 | HRH4 (0.75) | HRH4HRH1HTR3ABRD4PDE5A | |
| SCHEMBL21686911 | 0.88 | HRH4 (0.62) | HRH4HRH1ALDH1A1HTR3ABRD4 | |
| SCHEMBL21686942 | 0.88 | HRH4 (0.57) | HRH4HRH1KHKALDH1A1CYP1A2 | |
| SCHEMBL30763388 | 0.88 | HRH4 (0.57) | HRH4HRH1KHKALDH1A1CYP1A2 | |
| SCHEMBL30763437 | 0.87 | HRH4 (0.59) | HRH4HRH1HTR3ABRD4NPC1 | |
| SCHEMBL21687030 | 0.87 | HRH4 (0.59) | HRH4HRH1HTR3ABRD4NPC1 | |
| SCHEMBL21686914 | 0.86 | HRH4 (0.70) | HRH4HRH1HTR3ABRD4PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112739699-B | Pyridopyrimidine compounds as histamine H4 receptor inhibitors | 费斯制药股份有限公司 | 2023-11-28 | — | — | CN | disclosed |