Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27261707 | 0.87 | HPGD (0.43) | RAB9AHPGDLRRK2PIK3CD | |
| SCHEMBL30765359 | 0.83 | HSD17B10 (0.44) | HSD17B10NPC1ALOX5APFEN1RAB9A | |
| SCHEMBL27261301 | 0.82 | HSD17B10 (0.46) | HSD17B10NPC1ALOX5APFEN1RAB9A | |
| SCHEMBL27261708 | 0.77 | HPGD (0.45) | RAB9AHPGDPIK3CD | |
| SCHEMBL30765257 | 0.77 | HPGD (0.45) | RAB9AHPGDPIK3CD | |
| SCHEMBL30765169 | 0.75 | CCNT1 (0.37) | HSD17B10RAB9AHPGDLRRK2PIK3CD | |
| SCHEMBL27261390 | 0.73 | GLRA1 (0.37) | HSD17B10RAB9AHPGD | |
| SCHEMBL30765226 | 0.73 | MTOR (0.49) | RAB9AHPGDLRRK2PIK3CD | |
| SCHEMBL27261110 | 0.73 | MTOR (0.49) | RAB9AHPGDLRRK2PIK3CD | |
| SCHEMBL30765346 | 0.72 | PDE4B (0.36) | ALOX5APFEN1CAMK1DKCNH2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024033280-A1 | FUROPYRIDIN AND FUROPYRIMIDIN, INHIBITORS OF PI4K, FOR USE IN THE TREATMENT OF PARASITE INFECTION AND MALARIA | MERCK PATENT GMBH (DE) | 2024-02-15 | — | — | WO | disclosed |