Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.34 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL725211 | 0.83 | CCNC (0.40) | BRD4PIK3C3PIK3CGPIK3CBPIK3CD | |
| SCHEMBL30765349 | 0.83 | BRD4 (0.38) | BRD4ADORA2AADORA1ADORA2BCREBBP | |
| SCHEMBL30765399 | 0.80 | BRD4 (0.37) | BRD4ADORA2AADORA1ADORA2BCREBBP | |
| SCHEMBL725130 | 0.80 | PIK3C3 (0.36) | PIK3C3PIK3CGPIK3CBPIK3CDPIK3CA | |
| SCHEMBL723620 | 0.79 | CYP3A4 (0.38) | PIK3C3 | |
| SCHEMBL723480 | 0.78 | PIK3C3 (0.39) | PIK3C3PIK3CGPIK3CBPIK3CDPIK3CA | |
| SCHEMBL723291 | 0.78 | PIK3C3 (0.36) | PIK3C3PIK3CGPIK3CBPIK3CDPIK3CA | |
| SCHEMBL15216703 | 0.78 | PIK3C3 (0.38) | BRD4PIK3C3PIK3CGPIK3CBPIK3CD | |
| SCHEMBL27260818 | 0.77 | KCNH2 (0.37) | BRD4PIK3CBPIK3CDADORA2AADORA1 | |
| SCHEMBL725049 | 0.77 | PIM1 (0.41) | BMPR1BBMPR1AACVRL1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024033280-A1 | FUROPYRIDIN AND FUROPYRIMIDIN, INHIBITORS OF PI4K, FOR USE IN THE TREATMENT OF PARASITE INFECTION AND MALARIA | MERCK PATENT GMBH (DE) | 2024-02-15 | — | — | WO | disclosed |