SCHEMBL30765786

SCHEMBL30765786

O=C(Cn1c(-c2ccccc2)cnc(NCc2ccc(Oc3ccccc3)cc2)c1=O)NCc1cc2cnccc2[nH]1

nearest known ligand 0.48

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
F2 P00734 12/20 0.48
F3 P13726 7/20 0.48
F7 P08709 6/20 0.48
NTRK1 P04629 2/20 0.42
NTRK3 Q16288 1/20 0.41
KDM4C Q9H3R0 1/20 0.40
HDAC6 Q9UBN7 1/20 0.39
DGAT2 Q96PD7 1/20 0.39
PRSS1 P07477 2/20 0.39
PRSS2 P07478 1/20 0.38
PRSS3 P35030 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23474448 0.94 F2 (0.48) F2F3F7NTRK1NTRK3
SCHEMBL30765597 0.93 F2 (0.51) F2F3F7NTRK1NTRK3
SCHEMBL23474319 0.93 F2 (0.53) F2F3F7NTRK1NTRK3
SCHEMBL23474223 0.91 F2 (0.49) F2F3F7NTRK1NTRK3
SCHEMBL23460598 0.91 F2 (0.49) F2F3F7NTRK1NTRK3
SCHEMBL23474444 0.90 F2 (0.49) F2F3F7
Trifluoroacetic Acid SCHEMBL23460813 0.89 F2 (0.49) F2F3F7NTRK1NTRK3
SCHEMBL23474404 0.88 F2 (0.46) F2F3F7NTRK1NTRK3
SCHEMBL23474396 0.88 F3 (0.47) F2F3F7NTRK1NTRK3
SCHEMBL23474433 0.87 F2 (0.56) F2F3F7PRSS1PRSS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4568666-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS Alexion Pharmaceuticals, Inc. (US) 2025-06-18 EP disclosed
CN-119768164-A Pharmaceutical compounds for treating complement-mediated disorders 阿雷克森制药公司 2025-04-04 CN disclosed
WO-2024035686-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS ALEXION PHARMACEUTICALS, INC. (US) 2024-02-15 WO disclosed