SCHEMBL30765985

SCHEMBL30765985

CS(=O)(=NC#N)c1ccc(CCCNc2cnc(-c3ccccc3)n(CC(=O)NCc3cc4cnccc4[nH]3)c2=O)cc1

nearest known ligand 0.38

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
NAMPT P43490 4/20 0.38
F2 P00734 7/20 0.37
PRSS1 P07477 1/20 0.37
ELANE P08246 8/20 0.37
NTRK1 P04629 1/20 0.36
F7 P08709 1/20 0.36
F3 P13726 1/20 0.36
CYP2C9 P11712 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30765789 0.97 F2 (0.38) NAMPTF2PRSS1ELANENTRK1
SCHEMBL30765527 0.91 NAMPT (0.44) NAMPTF2PRSS1ELANENTRK1
SCHEMBL30765918 0.90 NAMPT (0.41) NAMPTF2PRSS1NTRK1F7
SCHEMBL30765942 0.88 NAMPT (0.42) NAMPTF2PRSS1ELANENTRK1
SCHEMBL30765749 0.88 F2 (0.38) NAMPTF2PRSS1NTRK1F7
SCHEMBL30765711 0.87 F2 (0.42) NAMPTF2PRSS1
SCHEMBL30765820 0.86 CMA1 (0.40) F2PRSS1ELANENTRK1F7
SCHEMBL30765583 0.86 F2 (0.40) NAMPTF2PRSS1NTRK1F7
SCHEMBL30765437 0.85 HDAC6 (0.41) F2PRSS1ELANEF7F3
SCHEMBL30765875 0.84 F2 (0.42) NAMPTF2PRSS1NTRK1F7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4568666-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS Alexion Pharmaceuticals, Inc. (US) 2025-06-18 EP disclosed
WO-2024035686-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS ALEXION PHARMACEUTICALS, INC. (US) 2024-02-15 WO disclosed