Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 14/20 | 0.73 |
| ▸ | FGFR1 | P11362 | 14/20 | 0.60 |
| ▸ | FGFR2 | P21802 | 14/20 | 0.60 |
| ▸ | FGFR3 | P22607 | 12/20 | 0.60 |
| ▸ | BMPR1A | P36894 | 4/20 | 0.51 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.51 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.51 |
| ▸ | HAMP | P81172 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30767268 | 0.88 | FGFR2 (0.77) | ACVR1FGFR1FGFR2FGFR3BMPR1A | |
| SCHEMBL30434492 | 0.87 | ACVR1 (0.83) | ACVR1FGFR1FGFR2FGFR3BMPR1A | |
| SCHEMBL21808591 | 0.87 | ACVR1 (0.83) | ACVR1FGFR1FGFR2FGFR3BMPR1A | |
| SCHEMBL21846707 | 0.84 | ACVR1 (1.00) | ACVR1FGFR1FGFR2FGFR3BMPR1A | |
| SCHEMBL30767266 | 0.82 | ACVR1 (0.82) | ACVR1FGFR1FGFR2FGFR3BMPR1A | |
| SCHEMBL30767254 | 0.78 | ACVR1 (0.75) | ACVR1FGFR1FGFR2FGFR3BMPR1A | |
| SCHEMBL30767265 | 0.78 | ACVR1 (0.72) | ACVR1FGFR1FGFR2FGFR3BMPR1A | |
| SCHEMBL21808306 | 0.77 | FGFR2 (0.85) | ACVR1FGFR1FGFR2FGFR3BMPR1A | |
| SCHEMBL30434082 | 0.77 | FGFR2 (0.85) | ACVR1FGFR1FGFR2FGFR3BMPR1A | |
| SCHEMBL30767260 | 0.77 | ACVR1 (0.79) | ACVR1FGFR1FGFR2FGFR3BMPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3856348-B1 | PYRAZOLO[4,3-D]PYRIMIDINE COMPOUNDS AS ALK2 AND/OR FGFR MODULATORS | INCYTE CORP (US) | 2024-01-03 | — | — | EP | claimed |