Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.37 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.37 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.37 |
| ▸ | HAMP | P81172 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21815521 | 0.93 | FGFR2 (0.41) | FGFR2FGFR1CHRM4CHRM2CHRM1 | |
| SCHEMBL30767291 | 0.89 | FGFR2 (0.43) | HDAC1FGFR2FGFR1FGFR3MAP4K4 | |
| SCHEMBL21846697 | 0.89 | FGFR2 (0.43) | HDAC1FGFR2FGFR1FGFR3MAP4K4 | |
| SCHEMBL21846805 | 0.87 | MAP4K4 (0.44) | HDAC1FGFR2FGFR1FGFR3MAP4K4 | |
| SCHEMBL30767299 | 0.87 | MAP4K4 (0.44) | HDAC1FGFR2FGFR1FGFR3MAP4K4 | |
| SCHEMBL21808619 | 0.82 | ACVR1 (0.45) | FGFR2FGFR1FGFR3ACVR1BMPR1A | |
| SCHEMBL21808616 | 0.82 | ACVR1 (0.45) | FGFR2FGFR1FGFR3ACVR1BMPR1A | |
| SCHEMBL30767304 | 0.82 | MAP4K4 (0.38) | HDAC1FGFR2FGFR1FGFR3MAP4K4 | |
| SCHEMBL21891832 | 0.82 | MAP4K4 (0.38) | HDAC1FGFR2FGFR1FGFR3MAP4K4 | |
| SCHEMBL21808414 | 0.80 | FGFR1 (0.35) | HDAC1FGFR2FGFR1CHRM4CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12441731-B2 | Pyrazolopyrimidine compounds and uses thereof | INCYTE CORPORATION (US) | 2025-10-14 | — | — | US | disclosed |
| EP-3856348-B1 | PYRAZOLO[4,3-D]PYRIMIDINE COMPOUNDS AS ALK2 AND/OR FGFR MODULATORS | INCYTE CORP (US) | 2024-01-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12441731-B2 | Pyrazolopyrimidine compounds and uses thereof | ALK, FGFR1, FGFR2 | HDAC1 1732/4885FGFR2 3/4885FGFR1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.