Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 8/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | DGKA | P23743 | 1/20 | 0.31 |
| ▸ | DGKZ | Q13574 | 1/20 | 0.31 |
| ▸ | PRCP | P42785 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30767395 | 1.00 | GRM2 (0.34) | GRM2CHRM5HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL30767435 | 1.00 | GRM2 (0.34) | GRM2CHRM5HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL30767358 | 0.94 | GRM2 (0.36) | GRM2CHRM5HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL30767385 | 0.94 | GRM2 (0.37) | GRM2CHRM5HCRTR1HCRTR2 | |
| SCHEMBL30767569 | 0.94 | GRM2 (0.37) | GRM2CHRM5HCRTR1HCRTR2 | |
| SCHEMBL30767328 | 0.94 | GRM2 (0.37) | GRM2CHRM5HCRTR1HCRTR2 | |
| SCHEMBL30767498 | 0.91 | CHRM5 (0.33) | CHRM5PTGDR2 | |
| SCHEMBL30767360 | 0.91 | CHRM5 (0.33) | CHRM5PTGDR2 | |
| SCHEMBL30767573 | 0.91 | CYP19A1 (0.33) | — | |
| SCHEMBL30767393 | 0.91 | CYP19A1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4568960-A1 | BICYCLIC TETRAHYDROAZEPINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2025-06-18 | — | — | EP | claimed |
| WO-2024033458-A1 | BICYCLIC TETRAHYDROAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2024-02-15 | — | — | WO | claimed |
| EP-4568960-A1 | BICYCLIC TETRAHYDROAZEPINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2025-06-18 | — | — | EP | disclosed |
| WO-2024033458-A1 | BICYCLIC TETRAHYDROAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2024-02-15 | — | — | WO | disclosed |