Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | GCGR | P47871 | 4/20 | 0.33 |
| ▸ | GIPR | P48546 | 3/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.32 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | NPY1R | P25929 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | EDNRB | P24530 | 1/20 | 0.31 |
| ▸ | EDNRA | P25101 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31665008 | 0.95 | GRM2 (0.33) | GRM2GCGRGIPRCHRM5PLAT | |
| SCHEMBL30767590 | 0.93 | GRM2 (0.32) | GRM2GCGRGIPRCHRM5PLAT | |
| SCHEMBL30767466 | 0.93 | GRM2 (0.32) | GRM2GCGRGIPRCHRM5PLAT | |
| SCHEMBL30767451 | 0.93 | GRM2 (0.32) | GRM2GCGRGIPRCHRM5PLAT | |
| SCHEMBL30767443 | 0.91 | KCNH2 (0.33) | GRM2NPY1R | |
| SCHEMBL30767522 | 0.91 | KCNH2 (0.33) | GRM2NPY1R | |
| SCHEMBL30767646 | 0.91 | KCNH2 (0.33) | GRM2NPY1R | |
| SCHEMBL30767521 | 0.90 | GRM2 (0.34) | GRM2GCGRGIPRCHRM5 | |
| SCHEMBL30767440 | 0.90 | GRM2 (0.34) | GRM2GCGRGIPRCHRM5 | |
| SCHEMBL30767572 | 0.90 | GRM2 (0.34) | GRM2GCGRGIPRCHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4568960-A1 | BICYCLIC TETRAHYDROAZEPINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2025-06-18 | — | — | EP | disclosed |
| WO-2024033458-A1 | BICYCLIC TETRAHYDROAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2024-02-15 | — | — | WO | disclosed |