Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 17/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 15/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.34 |
| ▸ | SHBG | P04278 | 2/20 | 0.34 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | STS | P08842 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | SNCA | P37840 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30768443 | 1.00 | ESR1 (0.41) | ESR1ESR2HSD17B1SHBGAKR1B10 | |
| SCHEMBL30769150 | 1.00 | ESR1 (0.41) | ESR1ESR2HSD17B1SHBGAKR1B10 | |
| SCHEMBL30768876 | 1.00 | ESR1 (0.41) | ESR1ESR2HSD17B1SHBGAKR1B10 | |
| SCHEMBL30773586 | 0.87 | ESR1 (0.41) | ESR1ESR2HSD17B1SHBGAKR1B10 | |
| SCHEMBL30773574 | 0.87 | ESR1 (0.41) | ESR1ESR2HSD17B1SHBGAKR1B10 | |
| SCHEMBL30768811 | 0.85 | ESR1 (0.47) | ESR1ESR2 | |
| SCHEMBL30769175 | 0.85 | ESR1 (0.47) | ESR1ESR2 | |
| SCHEMBL29966359 | 0.84 | ESR1 (0.45) | ESR1ESR2 | |
| SCHEMBL29092227 | 0.84 | ESR1 (0.47) | ESR1ESR2 | |
| SCHEMBL29966597 | 0.84 | ESR1 (0.45) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543871-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND USE THEREOF | Relay Therapeutics, Inc. (US) | 2025-04-30 | — | — | EP | disclosed |
| WO-2024006781-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2024-01-04 | — | — | WO | disclosed |