Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 17/20 | 0.55 |
| ▸ | DDB1 | Q16531 | 16/20 | 0.55 |
| ▸ | USP2 | O75604 | 3/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30965596 | 0.90 | CRBN (0.56) | CRBNDDB1USP2CYP2D6ALDH1A1 | |
| SCHEMBL30830807 | 0.90 | DDB1 (0.56) | CRBNDDB1USP2CYP2D6ALDH1A1 | |
| SCHEMBL31342607 | 0.89 | DDB1 (0.64) | CRBNDDB1CYP2D6TP53CYP1A2 | |
| SCHEMBL21877147 | 0.89 | DDB1 (0.64) | CRBNDDB1CYP2D6TP53CYP1A2 | |
| Hydrochloric Acid SCHEMBL25239219 | 0.88 | DDB1 (0.63) | CRBNDDB1CYP2D6TP53CYP1A2 | |
| Hydrochloric Acid SCHEMBL29680695 | 0.88 | DDB1 (0.63) | CRBNDDB1CYP2D6TP53CYP1A2 | |
| SCHEMBL30769102 | 0.86 | CRBN (0.51) | CRBNDDB1USP2CYP2D6ALDH1A1 | |
| Hydrochloric Acid SCHEMBL25201580 | 0.85 | CRBN (0.50) | CRBNDDB1USP2CYP2D6ALDH1A1 | |
| Hydrochloric Acid SCHEMBL31728248 | 0.85 | CRBN (0.50) | CRBNDDB1USP2CYP2D6ALDH1A1 | |
| SCHEMBL30643547 | 0.84 | DDB1 (0.55) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4581025-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Auron Therapeutics, Inc. (US) | 2025-07-09 | — | — | EP | disclosed |
| EP-4543871-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND USE THEREOF | Relay Therapeutics, Inc. (US) | 2025-04-30 | — | — | EP | disclosed |
| WO-2024050078-A1 | PYRIDAZINON DERIVATIVES AS KAT2 DEGRADERS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | AURON THERAPEUTICS, INC. (US) | 2024-03-07 | — | — | WO | disclosed |
| WO-2024006781-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2024-01-04 | — | — | WO | disclosed |