Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 17/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 12/20 | 0.43 |
| ▸ | MLNR | O43193 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30768686 | 1.00 | ESR1 (0.43) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL30768750 | 1.00 | ESR1 (0.43) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL30768538 | 1.00 | ESR1 (0.43) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL30769044 | 0.99 | ESR1 (0.43) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL30768954 | 0.99 | ESR1 (0.43) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL27081332 | 0.95 | ESR1 (0.44) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL27081311 | 0.91 | ESR1 (0.51) | ESR1ESR2CYP19A1CRBN | |
| SCHEMBL27082734 | 0.91 | ESR1 (0.51) | ESR1ESR2CYP19A1CRBN | |
| SCHEMBL30768877 | 0.89 | ESR1 (0.44) | ESR1ESR2NR3C1SLC6A4HTR2B | |
| SCHEMBL30769229 | 0.89 | ESR1 (0.53) | ESR1ESR2SLC6A4HTR2BSLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543871-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND USE THEREOF | Relay Therapeutics, Inc. (US) | 2025-04-30 | — | — | EP | disclosed |
| EP-4317146-A1 | TETRAHYDRONAPHTHALENE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | Jiangsu Hengrui Pharmaceuticals Co., Ltd. (CN) | 2024-02-07 | — | — | EP | disclosed |
| WO-2024006781-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2024-01-04 | — | — | WO | disclosed |