Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23887281 | 1.00 | PIK3CA (0.34) | PIK3CACCNE2CDK1CDK4CCNB1 | |
| SCHEMBL30307518 | 0.88 | PIK3CA (0.35) | PIK3CACCNE2CDK1CDK4CCNB1 | |
| SCHEMBL23887148 | 0.88 | PIK3CA (0.35) | PIK3CACCNE2CDK1CDK4CCNB1 | |
| SCHEMBL23887048 | 0.88 | PIK3CA (0.34) | PIK3CACCNE2CDK1CDK4CCNB1 | |
| SCHEMBL23887389 | 0.84 | CCNE2 (0.33) | PIK3CACCNE2CDK1CDK4CCNB1 | |
| SCHEMBL30322367 | 0.83 | PIK3CA (0.33) | PIK3CACCNE2CDK1CDK4CCNB1 | |
| SCHEMBL23887360 | 0.83 | PDE2A (0.40) | PIK3CA | |
| SCHEMBL29202703 | 0.83 | PIK3CA (0.33) | PIK3CACCNE2CDK1CDK4CCNB1 | |
| SCHEMBL23887343 | 0.83 | PIK3CA (0.37) | PIK3CACCNE2CDK1CDK4CCNB1 | |
| SCHEMBL24913406 | 0.83 | PIK3CA (0.37) | PIK3CACCNE2CDK1CDK4CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4347040-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF CANCER | Petra Pharma Corporation (US) | 2024-04-10 | — | — | EP | disclosed |
| CN-117769546-A | Allosteric ketene inhibitors of phosphoinositide 3-kinase (PI 3K) for the treatment of disease | 佩特拉制药公司 | 2024-03-26 | — | — | CN | disclosed |