Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.71 |
| ▸ | JAK1 | P23458 | 15/20 | 0.71 |
| ▸ | JAK3 | P52333 | 12/20 | 0.68 |
| ▸ | TYK2 | P29597 | 5/20 | 0.68 |
| ▸ | RET | P07949 | 3/20 | 0.68 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.68 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.68 |
| ▸ | PAK4 | O96013 | 2/20 | 0.68 |
| ▸ | ABL1 | P00519 | 2/20 | 0.68 |
| ▸ | LTK | P29376 | 2/20 | 0.68 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.68 |
| ▸ | CLK2 | P49760 | 2/20 | 0.68 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.68 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.68 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.68 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.68 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.68 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.68 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.68 |
| ▸ | CAMK1D | Q8IU85 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31291530 | 1.00 | JAK2 (0.71) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL103295 | 1.00 | JAK2 (0.71) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL2381207 | 1.00 | JAK2 (0.71) | JAK2JAK1JAK3TYK2RET | |
| Trifluoroacetic Acid SCHEMBL30663320 | 0.91 | JAK2 (0.61) | JAK2JAK1JAK3TYK2RET | |
| Trifluoroacetic Acid SCHEMBL101615 | 0.91 | JAK2 (0.61) | JAK2JAK1JAK3TYK2RET | |
| Trifluoroacetic Acid SCHEMBL100405 | 0.91 | JAK2 (0.61) | JAK2JAK1JAK3TYK2RET | |
| Trifluoroacetic Acid SCHEMBL30663370 | 0.91 | JAK2 (0.61) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL101171 | 0.89 | JAK2 (0.66) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL102143 | 0.89 | JAK2 (0.66) | JAK2JAK1JAK3TYK2RET | |
| SCHEMBL30054745 | 0.89 | JAK2 (0.66) | JAK2JAK1JAK3TYK2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4565229-A1 | TREATMENT OF URTICARIA USING JAK INHIBITORS | Incyte Corporation (US) | 2025-06-11 | — | — | EP | claimed |
| WO-2024030600-A1 | TREATMENT OF URTICARIA USING JAK INHIBITORS | INCYTE CORPORATION (US) | 2024-02-08 | — | — | WO | claimed |
| EP-4565229-A1 | TREATMENT OF URTICARIA USING JAK INHIBITORS | Incyte Corporation (US) | 2025-06-11 | — | — | EP | disclosed |
| WO-2024030600-A1 | TREATMENT OF URTICARIA USING JAK INHIBITORS | INCYTE CORPORATION (US) | 2024-02-08 | — | — | WO | disclosed |