Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 10/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.43 |
| ▸ | NEK2 | P51955 | 5/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | CSK | P41240 | 1/20 | 0.40 |
| ▸ | SIK1 | P57059 | 1/20 | 0.40 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.40 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27030611 | 1.00 | FLT3 (0.49) | FLT3GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL25425217 | 0.88 | FLT3 (0.50) | FLT3NEK2AURKAABL1KDR | |
| SCHEMBL27030692 | 0.83 | FLT3 (0.47) | FLT3NEK2AURKAABL1KDR | |
| SCHEMBL27030682 | 0.78 | FGFR3 (0.48) | FLT3NEK2AURKAABL1KDR | |
| SCHEMBL25425822 | 0.75 | FLT3 (0.45) | FLT3NEK2AURKAABL1KDR | |
| SCHEMBL27030656 | 0.69 | ALK (0.48) | FLT3KDRFGFR3 | |
| SCHEMBL30441169 | 0.68 | MKNK1 (0.44) | FLT3EGLN2PIK3CA | |
| SCHEMBL31501407 | 0.67 | FLT3 (0.50) | FLT3GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL25605557 | 0.67 | FLT3 (0.50) | FLT3GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL27030641 | 0.67 | KDR (0.47) | FLT3KDRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12600719-B2 | Salt inducible kinase inhibitors | THE GENERAL HOSPITAL CORPORATION (US) | 2026-04-14 | — | — | US | disclosed |
| WO-2024233967-A2 | SIK INHIBITORS TO TREAT CHRONIC KIDNEY DISEASE | THE GENERAL HOSPITAL CORPORATION (US) | 2024-11-14 | — | — | WO | disclosed |
| US-20240025892-A1 | SALT INDUCIBLE KINASE INHIBITORS | THE GENERAL HOSPITAL CORPORATION | 2024-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12600719-B2 | Salt inducible kinase inhibitors | GRK6, SGK1, CSNK1A1 | FLT3 2994/4885GABRA1 2275/4885GABRG2 2532/4885 |
| US-20240025892-A1 | SALT INDUCIBLE KINASE INHIBITORS | SGK1, SGK2, SIK1 | FLT3 1688/4885GABRA1 3498/4885GABRG2 3364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.