Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1605148 | 1.00 | HSD17B10 (0.42) | HSD17B10ADORA2AADORA1HRH4HSP90AA1 | |
| SCHEMBL12707369 | 0.88 | HSD17B10 (0.34) | HSD17B10ADORA2AADORA1 | |
| SCHEMBL2652226 | 0.83 | HSP90AA1 (0.38) | HSD17B10ADORA2AADORA1HSP90AA1HSP90AB1 | |
| SCHEMBL2657204 | 0.83 | HSP90AA1 (0.38) | HSD17B10ADORA2AADORA1HSP90AA1HSP90AB1 | |
| SCHEMBL2651105 | 0.83 | ADORA2A (0.35) | HSD17B10ADORA2AADORA1HSP90AA1HSP90AB1 | |
| SCHEMBL30754263 | 0.77 | HSP90AA1 (0.45) | HSD17B10ADORA2AADORA1HSP90AA1HSP90AB1 | |
| SCHEMBL2651405 | 0.77 | HSP90AA1 (0.45) | HSD17B10ADORA2AADORA1HSP90AA1HSP90AB1 | |
| SCHEMBL12707361 | 0.77 | ADORA2A (0.32) | ADORA2AADORA1 | |
| SCHEMBL13172396 | 0.74 | KDM4E (0.31) | KDM4E | |
| SCHEMBL278834 | 0.74 | KDM4E (0.31) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4568746-A1 | BICYCLIC TETRAHYDROTHIAZEPINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2025-06-18 | — | — | EP | disclosed |
| CN-119768401-A | Bicyclic tetrahydrothiazepine derivatives | 豪夫迈·罗氏有限公司 | 2025-04-04 | — | — | CN | disclosed |