SCHEMBL30779686

SCHEMBL30779686

CCCN(C(=O)c1cc(C(C)C)c(O)cc1O)c1cccc(C(=O)N2CCOCC2)c1

nearest known ligand 0.56

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 8/20 0.56
HSP90AB1 P08238 3/20 0.56
CYP3A4 P08684 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2B6 P20813 1/20 0.46
CYP2C19 P33261 1/20 0.46
MET P08581 1/20 0.44
EZH2 Q15910 2/20 0.44
NPC1 O15118 1/20 0.42
TP53 P04637 1/20 0.42
RAB9A P51151 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.41
HPGD P15428 1/20 0.41
PDK2 Q15119 1/20 0.40
PDK4 Q16654 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21644677 1.00 HSP90AA1 (0.56) HSP90AA1HSP90AB1CYP3A4CYP2C9CYP2B6
SCHEMBL21644517 0.90 HSP90AA1 (0.59) HSP90AA1HSP90AB1CYP3A4CYP2C9CYP2B6
SCHEMBL20509059 0.86 HSP90AA1 (0.61) HSP90AA1HSP90AB1CYP3A4CYP2C9CYP2B6
SCHEMBL21644710 0.86 HSP90AA1 (0.61) HSP90AA1HSP90AB1RAB9AL3MBTL1HPGD
SCHEMBL30779632 0.86 HSP90AA1 (0.61) HSP90AA1HSP90AB1RAB9AL3MBTL1HPGD
SCHEMBL30779550 0.84 HSP90AA1 (0.48) HSP90AA1HSP90AB1CYP3A4CYP2C9CYP2B6
SCHEMBL21644579 0.84 HSP90AA1 (0.48) HSP90AA1HSP90AB1CYP3A4CYP2C9CYP2B6
SCHEMBL21644530 0.83 HSP90AA1 (0.61) HSP90AA1HSP90AB1CYP3A4CYP2C9CYP2B6
SCHEMBL21644660 0.82 HSP90AA1 (0.61) HSP90AA1HSP90AB1CYP3A4CYP2C9CYP2B6
SCHEMBL21644618 0.81 HSP90AA1 (0.52) HSP90AA1HSP90AB1CYP3A4CYP2C9CYP2B6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111164074-B Heat shock protein 90 inhibitors 台北医学大学 2024-02-02 CN disclosed