SCHEMBL30780258

SCHEMBL30780258

CCC(=O)c1cc(C)c(-c2cc3cnc(NC(=O)[C@H]4C[C@H]4F)cc3c3ncoc23)cn1

nearest known ligand 0.44

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 18/20 0.44
MAP4K1 Q92918 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30780268 0.93 ABL1 (0.44) ABL1MAP4K1
SCHEMBL27135861 0.87 ABL1 (0.51) ABL1MAP4K1
SCHEMBL27135914 0.87 ABL1 (0.51) ABL1MAP4K1
SCHEMBL27135865 0.87 ABL1 (0.51) ABL1MAP4K1
SCHEMBL27153114 0.82 MAP4K1 (0.47) ABL1MAP4K1
SCHEMBL30780158 0.82 MAP4K1 (0.47) ABL1MAP4K1
SCHEMBL30780195 0.81 ABL1 (0.51) ABL1MAP4K1
SCHEMBL30780222 0.81 ABL1 (0.51) ABL1MAP4K1
SCHEMBL30780184 0.81 ABL1 (0.51) ABL1MAP4K1
SCHEMBL27135753 0.81 ABL1 (0.51) ABL1MAP4K1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4577546-A1 NAPHTHYRIDINE COMPOUNDS FOR INHIBITION OF RAF KINASES Enliven Inc. (US) 2025-07-02 EP disclosed
CN-120129682-A Naphthyridine compounds for inhibition of RAF kinase 英莱汶公司 2025-06-10 CN disclosed
WO-2024044713-A1 NAPHTHYRIDINE COMPOUNDS FOR INHIBITION OF RAF KINASES ENLIVEN INC. (US) 2024-02-29 WO disclosed