SCHEMBL30780276

SCHEMBL30780276

CCC(=O)c1cc(C)c(-c2cc3cnc(Cl)cc3c3sc(N)nc23)cn1

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.32
ABL1 P00519 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27139779 1.00 HTT (0.32) HTTABL1
SCHEMBL27139460 0.84 ABL1 (0.32) ABL1
SCHEMBL30780169 0.84 ABL1 (0.32) ABL1
SCHEMBL27138971 0.81 ABL1 (0.33) ABL1
SCHEMBL30780124 0.81 ABL1 (0.33) ABL1
SCHEMBL30780178 0.80 ABL1 (0.33) ABL1
SCHEMBL27141005 0.80 ABL1 (0.33) ABL1
SCHEMBL30780206 0.78 ABL1 (0.32) ABL1
SCHEMBL30780254 0.78 ABL1 (0.32) ABL1
SCHEMBL27150948 0.78 ABL1 (0.32) ABL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4577546-A1 NAPHTHYRIDINE COMPOUNDS FOR INHIBITION OF RAF KINASES Enliven Inc. (US) 2025-07-02 EP disclosed
CN-120129682-A Naphthyridine compounds for inhibition of RAF kinase 英莱汶公司 2025-06-10 CN disclosed
WO-2024044713-A1 NAPHTHYRIDINE COMPOUNDS FOR INHIBITION OF RAF KINASES ENLIVEN INC. (US) 2024-02-29 WO disclosed