Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 19/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 3/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | STAT1 | P42224 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26983714 | 0.85 | TYK2 (0.43) | TYK2JAK2JAK1STAT3JAK3 | |
| SCHEMBL30780374 | 0.85 | TYK2 (0.43) | TYK2JAK2JAK1STAT3JAK3 | |
| SCHEMBL30780316 | 0.83 | TYK2 (0.43) | TYK2JAK2JAK1STAT3STAT1 | |
| SCHEMBL26983745 | 0.83 | TYK2 (0.43) | TYK2JAK2JAK1STAT3STAT1 | |
| SCHEMBL26991434 | 0.82 | TYK2 (0.43) | TYK2JAK2JAK1STAT3STAT1 | |
| SCHEMBL30780280 | 0.81 | MAP4K1 (0.40) | TYK2JAK2JAK1 | |
| SCHEMBL26991458 | 0.80 | TYK2 (0.47) | TYK2JAK2JAK1STAT3STAT1 | |
| SCHEMBL26991433 | 0.80 | TYK2 (0.50) | TYK2JAK2JAK1STAT3STAT1 | |
| SCHEMBL30780454 | 0.79 | TYK2 (0.59) | TYK2JAK2JAK1 | |
| SCHEMBL26983735 | 0.79 | TYK2 (0.59) | TYK2JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4551559-A1 | HETEROARYL COMPOUNDS AS INHIBITORS OF TYK2/JAK1, COMPOSITION AND APPLICATION THEREOF | Accro Bioscience (HK) Limited (HK) | 2025-05-14 | — | — | EP | disclosed |
| WO-2024010963-A1 | HETEROARYL COMPOUNDS AS INHIBITORS OF TYK2/JAK1, COMPOSITION AND APPLICATION THEREOF | ACCRO BIOSCIENCE (HK) LIMITED (CN) | 2024-01-11 | — | — | WO | disclosed |