Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL216813 | 1.00 | MAPT (0.55) | MAPTGAATSHRMAPK1HTT | |
| SCHEMBL27685404 | 0.85 | MAPT (0.52) | MAPTGAATSHRMAPK1HTT | |
| SCHEMBL2596460 | 0.84 | MAPT (0.71) | MAPTGAATSHRMAPK1HTT | |
| SCHEMBL31305215 | 0.84 | MAPT (0.71) | MAPTGAATSHRMAPK1HTT | |
| SCHEMBL10021493 | 0.82 | MAPT (0.53) | MAPTGAATSHRMAPK1HTT | |
| SCHEMBL11440396 | 0.82 | MAPT (0.57) | MAPTGAATSHRMAPK1HTT | |
| SCHEMBL3003760 | 0.82 | MAPT (0.57) | MAPTGAATSHRMAPK1HTT | |
| SCHEMBL5009932 | 0.81 | MAPT (0.56) | MAPTGAATSHRMAPK1HTT | |
| SCHEMBL7598124 | 0.80 | SMN1; SMN2 (0.48) | MAPTGAATSHRMAPK1HTT | |
| SCHEMBL10288226 | 0.80 | MAPT (0.55) | MAPTGAATSHRMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024030651-A1 | GPX4 INHIBITORS AND USE THEREOF | SONATA THERAPEUTICS, INC. (US) | 2024-02-08 | — | — | WO | disclosed |