Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.57 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.52 |
| ▸ | THRB | P10828 | 3/20 | 0.42 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28081763 | 1.00 | TSHR (0.57) | TSHRDNM1THRBFAAHNAAA | |
| Dymanthine SCHEMBL9482671 | 1.00 | TSHR (0.57) | TSHRDNM1THRBFAAHNAAA | |
| Bromide SCHEMBL9481787 | 1.00 | TSHR (0.57) | TSHRDNM1THRBFAAHNAAA | |
| SCHEMBL16826393 | 0.98 | TSHR (0.59) | TSHRDNM1THRBFAAHNAAA | |
| SCHEMBL22028076 | 0.98 | TSHR (0.59) | TSHRDNM1THRBFAAHNAAA | |
| SCHEMBL16826283 | 0.98 | TSHR (0.59) | TSHRDNM1THRBFAAHNAAA | |
| Dymanthine SCHEMBL29458568 | 0.98 | TSHR (0.59) | TSHRDNM1THRBFAAHNAAA | |
| Decane SCHEMBL27941727 | 0.86 | TSHR (0.74) | TSHRTHRBFAAHNAAATHRA | |
| Hydrochloric Acid SCHEMBL9133862 | 0.86 | TSHR (0.75) | TSHRDNM1THRBNAAATHRA | |
| Iodide SCHEMBL9578520 | 0.86 | TSHR (0.65) | TSHRDNM1THRBNAAATHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004076811-A2 | DRILLING FLUID COMPONENT | HALLIBURTON ENERGY SERVICES, INC. (US) | 2004-09-10 | — | — | WO | claimed |
| US-20040171495-A1 | Drilling fluid component | HALLIBURTON ENERGY SERVICES, INC. | 2004-09-02 | — | — | US | claimed |
| CN-116457440-A | Substituted alkanolamine scale inhibitors | 哈利伯顿能源服务公司 | 2023-07-18 | — | — | CN | disclosed |
| CN-102333840-B | Treatment fluids comprising relative permeability modifiers and methods of use | 哈利伯顿能源服务公司 | 2016-08-31 | — | — | CN | disclosed |
| US-8962535-B2 | Methods of diverting chelating agents in subterranean treatments | HALLIBURTON ENERGY SERVICES, INC. (US) | 2015-02-24 | — | — | US | disclosed |
| US-8631869-B2 | Methods useful for controlling fluid loss in subterranean treatments | HALLIBURTON ENERGY SERVICES, INC. | 2014-01-21 | — | — | US | disclosed |
| US-8592353-B2 | Methods useful for diverting aqueous fluids in subterranean operations | HALLIBURTON ENERGY SERVICES, INC. (US) | 2013-11-26 | — | — | US | disclosed |
| US-8418764-B2 | Methods useful for controlling fluid loss in subterranean formations | HALLIBURTON ENERGY SERVICES, INC. (US) | 2013-04-16 | — | — | US | disclosed |
| US-8278250-B2 | penetrating a well bore with a first portion of an aqueous solution of a water-soluble polymer with hydrophobic or hydrophilic modification to divert a second portion of the treatment fluid or another aqueous treatment fluid to another portion of the subterranean formation | HALLIBURTON ENERGY SERVICES, INC. (US) | 2012-10-02 | — | — | US | disclosed |
| US-8251141-B2 | Methods useful for controlling fluid loss during sand control operations | HALLIBURTON ENERGY SERVICES, INC. (US) | 2012-08-28 | — | — | US | disclosed |
| US-20120168166-A1 | Methods Useful for Diverting Aqueous Fluids in Subterranean Operations | HALLIBURTON ENERGY SERVICES, INC. (US) | 2012-07-05 | — | — | US | disclosed |
| US-7114568-B2 | Hydrophobically modified polymers for a well completion spacer fluid | HALLIBURTON ENERGY SERVICES, INC. (US) | 2006-10-03 | — | — | US | disclosed |
| US-20060137875-A1 | Methods useful for controlling fluid loss in subterranean formations | HALLIBURTON ENERGY SERVICES, INC. | 2006-06-29 | — | — | US | disclosed |
| US-20050284632-A1 | Methods useful for controlling fluid loss during sand control operations | HALLIBURTON ENERGY SERVICES, INC. | 2005-12-29 | — | — | US | disclosed |
| US-20050230116-A1 | Methods and compositions for use with spacer fluids used in subterranean well bores | HALLIBURTON ENERGY SERVICES, INC. | 2005-10-20 | — | — | US | disclosed |
| US-20050230114-A1 | Hydrophobically modified polymers for a well completion spacer fluid | HALLIBURTON ENERGY SERVICES, INC. | 2005-10-20 | — | — | US | disclosed |
| US-20050199396-A1 | Methods useful for controlling fluid loss in subterranean treatments | HALLIBURTON ENERGY SERVICES, INC. | 2005-09-15 | — | — | US | disclosed |
| US-20050194140-A1 | Methods useful for diverting aqueous fluids in subterranean operations | HALLIBURTON ENERGY SERVICES, INC. | 2005-09-08 | — | — | US | disclosed |
| WO-2004076811-A2 | DRILLING FLUID COMPONENT | HALLIBURTON ENERGY SERVICES, INC. (US) | 2004-09-10 | — | — | WO | disclosed |
| US-5270046-A | Heparin bound anti-thrombotic material | UBE INDUSTRIES, LTD. (JP) | 1993-12-14 | — | — | US | disclosed |