SCHEMBL30788263

SCHEMBL30788263

O=C1CSc2ccc(C(=O)Nc3cccc(S(=O)(=O)Nc4ccc(Br)cc4)c3)cc2N1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 9/20 1.00
▸ KMT2A Q03164 9/20 1.00
▸ HTT P42858 8/20 1.00
▸ MAPT P10636 8/20 1.00
▸ LMNA P02545 7/20 1.00
▸ SMN1; SMN2 Q16637 7/20 1.00
▸ ALDH1A1 P00352 5/20 1.00
▸ MAPK1 P28482 3/20 1.00
▸ NPSR1 Q6W5P4 1/20 1.00
▸ KDM4E B2RXH2 3/20 0.71
▸ NPC1 O15118 2/20 0.71
▸ ADORA3 P0DMS8 1/20 0.60
▸ SLC6A3 Q01959 1/20 0.60
▸ NOD2 Q9HC29 1/20 0.53
▸ PKM P14618 2/20 0.49
▸ ALOX12 P18054 1/20 0.49
▸ RAB9A P51151 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27179487 1.00 MEN1 (1.00) MEN1KMT2AHTTMAPTLMNA
SCHEMBL24124322 0.86 KMT2A (0.75) MEN1KMT2AHTTMAPTLMNA
SCHEMBL25920764 0.80 MAPT (0.66) MEN1KMT2AHTTMAPTLMNA
SCHEMBL25920766 0.77 MAPT (0.72) MEN1KMT2AHTTMAPTLMNA
SCHEMBL6269502 0.76 MEN1 (1.00) MEN1KMT2AHTTMAPTLMNA
SCHEMBL27179498 0.76 MAPT (0.71) MEN1KMT2AHTTMAPTLMNA
SCHEMBL30926693 0.76 MAPT (0.71) MEN1KMT2AHTTMAPTLMNA
SCHEMBL30926711 0.76 MEN1 (0.92) MEN1KMT2AHTTMAPTLMNA
SCHEMBL4258411 0.76 MEN1 (0.92) MEN1KMT2AHTTMAPTLMNA
SCHEMBL30926949 0.75 MEN1 (0.70) MEN1KMT2AHTTMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4580404-A2 SULFONAMIDE APYRASE INHIBITORS Texas Crop Science, Inc. (US) 2025-07-09 — — EP claimed
WO-2024050041-A2 SULFONAMIDE APYRASE INHIBITORS TEXAS CROP SCIENCE (US) 2024-03-07 — — WO claimed
US-20240099300-A1 SULFONAMIDE APYRASE INHIBITORS TEXAS CROP SCIENCE, INC. 2024-03-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240099300-A1 SULFONAMIDE APYRASE INHIBITORS APEH, ARSA, DNPEP MEN1 4795/4885KMT2A 2544/4885HTT 4627/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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