Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30789695 | 0.97 | MAPT (0.45) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL30789380 | 0.93 | MAPT (0.37) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL30789446 | 0.85 | MTOR (0.38) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL30789618 | 0.84 | HTR2A (0.36) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL30789415 | 0.81 | MEN1 (0.39) | MEN1KMT2ANPC1RAB9AATM | |
| SCHEMBL30789403 | 0.78 | MEN1 (0.43) | MEN1KMT2ANPC1RAB9AATM | |
| SCHEMBL30789416 | 0.77 | CYP1A2 (0.31) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL30789491 | 0.76 | PRKCQ (0.39) | MAPTALDH1A1 | |
| SCHEMBL30789443 | 0.73 | MEN1 (0.33) | MEN1KMT2ANPC1RAB9AATM | |
| SCHEMBL30789654 | 0.73 | NPC1 (0.33) | MEN1KMT2ANPC1RAB9AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4587124-A1 | POLYCYCLIC QUINAZOLINES FOR INHIBITION OF ERBB2 | Enliven Inc. (US) | 2025-07-23 | — | — | EP | disclosed |
| WO-2024059558-A1 | POLYCYCLIC QUINAZOLINES FOR INHIBITION OF ERBB2 | ENLIVEN INC. (US) | 2024-03-21 | — | — | WO | disclosed |