Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYBB | P04839 | 1/20 | 0.35 |
| ▸ | NOX5 | Q96PH1 | 1/20 | 0.35 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.35 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30793378 | 0.88 | NR1H2 (0.43) | MEN1KMT2AESR2HPGDUSP2 | |
| SCHEMBL25336741 | 0.88 | MEN1 (0.38) | MEN1KMT2AESR2ADORA1HPGD | |
| SCHEMBL30793809 | 0.87 | MEN1 (0.36) | MEN1KMT2AESR2HPGDCKS1B | |
| SCHEMBL30793460 | 0.86 | MEN1 (0.38) | MEN1KMT2AESR2ADORA1HPGD | |
| SCHEMBL25335687 | 0.86 | MEN1 (0.43) | MEN1KMT2AESR2ADORA1HPGD | |
| SCHEMBL30793341 | 0.86 | MEN1 (0.38) | MEN1KMT2AESR2ADORA1HPGD | |
| SCHEMBL30793750 | 0.85 | ADORA1 (0.39) | MEN1KMT2AESR2ADORA1HPGD | |
| SCHEMBL30793790 | 0.85 | ADORA1 (0.43) | MEN1KMT2AESR2ADORA1HPGD | |
| SCHEMBL30793364 | 0.84 | CKS1B (0.36) | MEN1KMT2AESR2ADORA1HPGD | |
| SCHEMBL30793426 | 0.84 | MEN1 (0.39) | MEN1KMT2AESR2ADORA1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4540254-A1 | TETRAHYDROPYRIDOPYRIMIDINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2025-04-23 | — | — | EP | disclosed |
| WO-2023244604-A1 | TETRAHYDROPYRIDOPYRIMIDINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-12-21 | — | — | WO | disclosed |