SCHEMBL30795146

SCHEMBL30795146

O=C(CCC(=O)N1CCc2ccccc2C1C1CCCCC1)NCc1cccc(C(F)(F)F)c1

nearest known ligand 0.54

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 8/20 0.54
CYP2D6 P10635 9/20 0.49
HDAC3 O15379 1/20 0.46
HDAC8 Q9BY41 1/20 0.46
NCOR2 Q9Y618 1/20 0.46
HRH3 Q9Y5N1 1/20 0.45
CYP1A2 P05177 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3229646 1.00 KCNH2 (0.54) KCNH2CYP2D6HDAC3HDAC8NCOR2
SCHEMBL2307596 0.87 NPC1 (0.44) HRH3
SCHEMBL2304095 0.86 NPC1 (0.44) KCNH2HRH3CYP2C9CYP2C19
SCHEMBL2307060 0.86 NPC1 (0.45) HRH3
SCHEMBL30795036 0.85 DRD1 (0.48) HDAC8HRH3
SCHEMBL3243040 0.85 DRD1 (0.48) HDAC8HRH3
SCHEMBL3244115 0.83 HDAC1 (0.45) HDAC8HRH3
SCHEMBL30814250 0.83 HDAC1 (0.54) CYP2D6HDAC3HDAC8NCOR2
SCHEMBL30795865 0.83 HDAC1 (0.45) HDAC8HRH3
SCHEMBL3236404 0.83 HDAC1 (0.54) CYP2D6HDAC3HDAC8NCOR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4584250-A1 COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS Biohaven Therapeutics Ltd. (VG) 2025-07-16 EP disclosed
EP-4580679-A1 COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS AND NMDA RECEPTOR ANTAGONISTS Biohaven Therapeutics Ltd. (VG) 2025-07-09 EP disclosed
WO-2024054811-A1 COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS BIOHAVEN THERAPEUTICS LTD. (VG) 2024-03-14 WO disclosed
WO-2024054807-A1 COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS AND TDP-43 MODULATORS BIOHAVEN THERAPEUTICS LTD. (VG) 2024-03-14 WO disclosed
WO-2024050389-A1 COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS AND NMDA RECEPTOR ANTAGONISTS BIOHAVEN THERAPEUTICS LTD. (VG) 2024-03-07 WO disclosed