Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3920397 | 1.00 | GRM5 (0.45) | GRM5PDE10ANPC1ALDH1A1RAB9A | |
| SCHEMBL3923675 | 0.82 | GRM5 (0.45) | GRM5PDE10AKDRDYRK1BFLT3 | |
| SCHEMBL5221946 | 0.81 | NPC1 (0.40) | NPC1ALDH1A1RAB9ASMN1; SMN2KDR | |
| SCHEMBL5668086 | 0.78 | KDR (0.55) | GRM5PDE10AALDH1A1KDRDYRK1B | |
| SCHEMBL14381068 | 0.76 | GRM5 (0.50) | GRM5PDE10AKDRDYRK1BFLT3 | |
| SCHEMBL5215794 | 0.76 | GRM5 (0.50) | GRM5PDE10AALDH1A1SMN1; SMN2KDR | |
| SCHEMBL15945076 | 0.75 | GRM5 (0.66) | GRM5PDE10AKDRGRM4 | |
| SCHEMBL3928550 | 0.74 | GRM5 (0.51) | GRM5PDE10ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8357647 | 0.72 | GRM5 (0.49) | GRM5PDE10AKDRDYRK1BFLT3 | |
| SCHEMBL30795649 | 0.72 | GRM5 (0.58) | GRM5PDE10AKDRDYRK1BFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4584250-A1 | COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS | Biohaven Therapeutics Ltd. (VG) | 2025-07-16 | — | — | EP | disclosed |
| WO-2024054811-A1 | COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS | BIOHAVEN THERAPEUTICS LTD. (VG) | 2024-03-14 | — | — | WO | disclosed |