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SCHEMBL30798264

SCHEMBL30798264

CNC(=O)COc1cc2cc(Nc3nc(N4CCC(OC5CC(N6CC7(CCN(c8ccc9c(c8)C(=O)N(C8CCC(=O)NC8=O)C9=O)CC7)C6)C5)CC4)ncc3Cl)ccc2n(C(C)C)c1=O

nearest known ligand 0.46

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ BCL6 P41182 7/20 0.46
▸ MELK Q14680 1/20 0.46
▸ NCOR2 Q9Y618 4/20 0.46
▸ EGFR P00533 9/20 0.42
▸ ERBB2 P04626 2/20 0.42
▸ PTK2 Q05397 1/20 0.42
▸ ERBB3 P21860 2/20 0.42
▸ CHRM4 P08173 1/20 0.39
▸ BCL6B Q8N143 1/20 0.39
▸ BTK Q06187 1/20 0.38
▸ ALK Q9UM73 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24718138 1.00 BCL6 (0.46) BCL6MELKNCOR2EGFRERBB2
SCHEMBL30894407 1.00 BCL6 (0.46) BCL6MELKNCOR2EGFRERBB2
SCHEMBL24717551 0.98 BCL6 (0.46) BCL6MELKNCOR2EGFRERBB2
SCHEMBL30894100 0.98 BCL6 (0.46) BCL6MELKNCOR2EGFRERBB2
SCHEMBL30894364 0.98 BCL6 (0.46) BCL6MELKNCOR2EGFRERBB2
SCHEMBL24718765 0.98 BCL6 (0.46) BCL6MELKNCOR2EGFRERBB2
SCHEMBL24717915 0.97 BCL6 (0.45) BCL6MELKNCOR2EGFRERBB2
SCHEMBL30894135 0.97 BCL6 (0.45) BCL6MELKNCOR2EGFRERBB2
SCHEMBL27220372 0.97 BCL6 (0.45) BCL6MELKNCOR2EGFRERBB2
SCHEMBL24718779 0.97 BCL6 (0.47) BCL6MELKNCOR2EGFRERBB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4323352-A1 MODULATORS OF BCL6 PROTEOLYSIS AND ASSOCIATED METHODS OF USE Arvinas Operations, Inc. (US) 2024-02-21 — — EP disclosed
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