Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 3/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | RORC | P51449 | 6/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | KLK7 | P49862 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26638016 | 1.00 | KMT2A (0.38) | KMT2AMEN1POLBNAMPTBTK | |
| SCHEMBL26638100 | 1.00 | KMT2A (0.38) | KMT2AMEN1POLBNAMPTBTK | |
| SCHEMBL29819410 | 0.90 | NAMPT (0.37) | KMT2AMEN1POLBNAMPTBTK | |
| SCHEMBL30798172 | 0.88 | NAMPT (0.36) | KMT2AMEN1POLBNAMPTBTK | |
| SCHEMBL26638095 | 0.88 | NAMPT (0.36) | KMT2AMEN1POLBNAMPTBTK | |
| SCHEMBL26638008 | 0.88 | NAMPT (0.36) | KMT2AMEN1POLBNAMPTBTK | |
| SCHEMBL30797961 | 0.88 | NAMPT (0.36) | KMT2AMEN1POLBNAMPTBTK | |
| SCHEMBL2277837 | 0.88 | BTK (0.42) | KMT2ANAMPTBTKL3MBTL1RORC | |
| SCHEMBL2291394 | 0.88 | BTK (0.42) | KMT2ANAMPTBTKL3MBTL1RORC | |
| SCHEMBL2293606 | 0.88 | BTK (0.42) | KMT2ANAMPTBTKL3MBTL1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118406052-A | Tricyclic JANUS kinase 1 inhibitors and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-30 | — | — | CN | disclosed |
| CN-113396150-B | Tricyclic JANUS kinase 1 inhibitors and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-03-12 | — | — | CN | disclosed |