Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | EED | O75530 | 1/20 | 0.43 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.43 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.43 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.43 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30798370 | 1.00 | PDE4B (0.45) | PDE4BJAK2JAK3PTK2EED | |
| SCHEMBL24717417 | 1.00 | PDE4B (0.45) | PDE4BJAK2JAK3PTK2EED | |
| SCHEMBL29152533 | 1.00 | PDE4B (0.45) | PDE4BJAK2JAK3PTK2EED | |
| SCHEMBL24717421 | 1.00 | PDE4B (0.45) | PDE4BJAK2JAK3PTK2EED | |
| SCHEMBL30606458 | 0.91 | PDE4B (0.53) | PDE4BJAK2JAK3PTK2EED | |
| SCHEMBL29152603 | 0.91 | JAK2 (0.43) | PDE4BJAK2JAK3PTK2EED | |
| SCHEMBL30798402 | 0.91 | JAK2 (0.43) | PDE4BJAK2JAK3PTK2EED | |
| SCHEMBL16991907 | 0.91 | PDE4B (0.53) | PDE4BJAK2JAK3PTK2EED | |
| SCHEMBL24717418 | 0.88 | PDE4B (0.45) | PDE4BEEDRBBP4SUZ12EZH2 | |
| SCHEMBL24717414 | 0.88 | PDE4B (0.45) | PDE4BEEDRBBP4SUZ12EZH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4323352-A1 | MODULATORS OF BCL6 PROTEOLYSIS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2024-02-21 | — | — | EP | disclosed |