Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 19/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.59 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | BLK | P51451 | 1/20 | 0.56 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.56 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.56 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24977927 | 1.00 | CHEK1 (0.59) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| SCHEMBL30101691 | 1.00 | CHEK1 (0.59) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| SCHEMBL30634793 | 0.92 | CHEK1 (0.71) | CHEK1KCNH2 | |
| SCHEMBL31507337 | 0.92 | CHEK1 (0.71) | CHEK1KCNH2 | |
| SCHEMBL31507350 | 0.88 | CHEK1 (0.76) | CHEK1KCNH2 | |
| SCHEMBL24935525 | 0.88 | CHEK1 (0.76) | CHEK1KCNH2 | |
| SCHEMBL24977607 | 0.86 | CHEK1 (0.75) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| SCHEMBL30106188 | 0.86 | CHEK1 (0.75) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| SCHEMBL30634785 | 0.86 | KCNH2 (0.63) | CHEK1KCNH2 | |
| SCHEMBL25318548 | 0.86 | CHEK1 (0.64) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117715905-A | Checkpoint kinase 1 (CHK 1) inhibitors and uses thereof | 无界生物公司 | 2024-03-15 | — | — | CN | disclosed |