Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 13/20 | 0.53 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.44 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 7/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24671237 | 0.89 | CRBN (0.51) | CRBNDDB1IKZF3PARP1BRD4 | |
| SCHEMBL24671244 | 0.88 | CRBN (0.58) | CRBNDDB1IKZF3PARP1BRD4 | |
| SCHEMBL30801203 | 0.88 | CRBN (0.58) | CRBNDDB1IKZF3PARP1BRD4 | |
| SCHEMBL24671242 | 0.87 | CRBN (0.57) | CRBNDDB1IKZF3PARP1BRD4 | |
| SCHEMBL24421608 | 0.86 | CRBN (0.56) | CRBNDDB1IKZF3PARP1BRD4 | |
| SCHEMBL31421641 | 0.86 | CRBN (0.52) | CRBNDDB1IKZF3PARP1 | |
| SCHEMBL31230636 | 0.86 | CRBN (0.52) | CRBNDDB1IKZF3PARP1 | |
| SCHEMBL31230794 | 0.86 | CRBN (0.52) | CRBNDDB1IKZF3PARP1 | |
| SCHEMBL25631633 | 0.86 | CRBN (0.52) | CRBNDDB1IKZF3PARP1 | |
| SCHEMBL25631627 | 0.86 | CRBN (0.52) | CRBNDDB1IKZF3PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693502-A | Compounds for inhibiting or degrading ITK, compositions comprising the same, methods of making the same, and methods of using the same | 纽力克斯治疗公司 | 2024-03-12 | — | — | CN | disclosed |