Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.50 |
| ▸ | SYK | P43405 | 15/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13734126 | 1.00 | MAPK8 (0.50) | MAPK8MAPK9SYKJAK2LRRK2 | |
| SCHEMBL14861944 | 0.89 | MAPK8 (0.40) | MAPK8MAPK9SYK | |
| SCHEMBL14861941 | 0.89 | MAPK8 (0.40) | MAPK8MAPK9SYK | |
| SCHEMBL25634102 | 0.78 | SYK (0.53) | MAPK8MAPK9SYK | |
| SCHEMBL17083657 | 0.78 | SYK (0.53) | MAPK8MAPK9SYK | |
| SCHEMBL15354453 | 0.78 | MAPK8 (0.55) | MAPK8MAPK9SYKJAK2MAPK1 | |
| SCHEMBL17485379 | 0.77 | MAPK8 (0.54) | MAPK8MAPK9SYKJAK2MAPK1 | |
| SCHEMBL13735693 | 0.76 | JAK3 (0.53) | SYKJAK2 | |
| SCHEMBL13735202 | 0.76 | MAPK8 (0.55) | MAPK8MAPK9SYKJAK2 | |
| SCHEMBL15354455 | 0.75 | MAPK8 (0.63) | MAPK8MAPK9SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111471021-B | Substituted diamino carboxamides and diamino carbonitrile pyrimidines, compositions thereof, and methods of treatment therewith | 西格诺药品有限公司 | 2024-04-02 | — | — | CN | disclosed |
| EP-4328223-A2 | SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | Signal Pharmaceuticals, LLC (US) | 2024-02-28 | — | — | EP | disclosed |