Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 13/20 | 0.55 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.55 |
| ▸ | WIZ | O95785 | 4/20 | 0.52 |
| ▸ | GSPT1 | P15170 | 2/20 | 0.49 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 4/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | IKZF2 | Q9UKS7 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30805397 | 0.95 | CRBN (0.57) | CRBNDDB1WIZGSPT1IKZF3 | |
| SCHEMBL30400916 | 0.88 | CRBN (0.55) | CRBNDDB1GSPT1IKZF3CSNK1A1 | |
| SCHEMBL30400720 | 0.88 | CRBN (0.55) | CRBNDDB1GSPT1IKZF3CSNK1A1 | |
| SCHEMBL22906959 | 0.87 | CRBN (0.56) | CRBNDDB1WIZGSPT1IKZF3 | |
| SCHEMBL30919857 | 0.87 | CRBN (0.55) | CRBNDDB1WIZGSPT1CSNK1A1 | |
| SCHEMBL27091258 | 0.87 | CRBN (0.55) | CRBNDDB1WIZGSPT1CSNK1A1 | |
| SCHEMBL30919733 | 0.86 | CRBN (0.54) | CRBNDDB1WIZGSPT1CSNK1A1 | |
| SCHEMBL22512077 | 0.86 | CRBN (0.54) | CRBNDDB1WIZGSPT1CSNK1A1 | |
| SCHEMBL23317936 | 0.85 | CRBN (0.71) | CRBNDDB1 | |
| SCHEMBL20232060 | 0.85 | CRBN (0.74) | CRBNDDB1GSPT1IKZF3CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054625-A2 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING KRAS G12D VIA UBIQUITIN PROTEASOME PATHWAY | NIKANG THERAPEUTICS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |