Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 16/20 | 0.72 |
| ▸ | DDB1 | Q16531 | 15/20 | 0.72 |
| ▸ | STAT3 | P40763 | 3/20 | 0.52 |
| ▸ | GRAMD1A | Q96CP6 | 1/20 | 0.50 |
| ▸ | TNF | P01375 | 1/20 | 0.49 |
| ▸ | IL1B | P01584 | 1/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.49 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.49 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24620977 | 1.00 | CRBN (0.72) | CRBNDDB1STAT3GRAMD1ATNF | |
| SCHEMBL31307125 | 1.00 | CRBN (0.72) | CRBNDDB1STAT3GRAMD1ATNF | |
| SCHEMBL23842551 | 1.00 | CRBN (0.72) | CRBNDDB1STAT3GRAMD1ATNF | |
| SCHEMBL21071278 | 0.97 | CRBN (0.74) | CRBNDDB1STAT3TNFIL1B | |
| SCHEMBL21069931 | 0.96 | CRBN (0.69) | CRBNDDB1STAT3GRAMD1ATNF | |
| SCHEMBL21070004 | 0.95 | CRBN (0.68) | CRBNDDB1STAT3GRAMD1A | |
| SCHEMBL21227737 | 0.93 | DDB1 (0.77) | CRBNDDB1STAT3TNFIL1B | |
| SCHEMBL21071039 | 0.92 | CRBN (0.70) | CRBNDDB1STAT3GRAMD1A | |
| SCHEMBL21070933 | 0.91 | CRBN (0.69) | CRBNDDB1STAT3GRAMD1A | |
| SCHEMBL21070296 | 0.91 | CRBN (0.69) | CRBNDDB1STAT3GRAMD1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054625-A2 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING KRAS G12D VIA UBIQUITIN PROTEASOME PATHWAY | NIKANG THERAPEUTICS, INC. (US) | 2024-03-14 | — | — | WO | disclosed |