Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 4/20 | 0.47 |
| ▸ | AKT2 | P31751 | 4/20 | 0.47 |
| ▸ | AKT3 | Q9Y243 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.40 |
| ▸ | MTOR | P42345 | 3/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30808158 | 0.92 | AKT1 (0.56) | AKT1AKT2AKT3MAPTLMNA | |
| SCHEMBL30808169 | 0.87 | PIK3CB (0.53) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL30808195 | 0.80 | AKT1 (0.67) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL30808186 | 0.80 | AKT1 (0.67) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL30808212 | 0.80 | AKT1 (0.67) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL30808187 | 0.80 | AKT1 (0.71) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL30808170 | 0.80 | AKT1 (0.71) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL30808161 | 0.78 | PIK3CA (0.64) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL30808153 | 0.78 | PIK3CA (0.64) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL30808204 | 0.78 | PIK3CA (0.64) | AKT1AKT2AKT3PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024026419-A1 | QUINOXALINE DERIVATIVES AS PIK3 ALPHA MODULATORS | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2024-02-01 | — | — | WO | disclosed |