Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 4/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
| ▸ | ITK | Q08881 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759491 | 0.91 | PDGFRA (0.63) | PDGFRACHRM1HRH3IRAK4KIT | |
| SCHEMBL24577609 | 0.91 | PDGFRA (0.63) | PDGFRACHRM1HRH3IRAK4KIT | |
| SCHEMBL29759485 | 0.89 | PDGFRA (0.63) | PDGFRACHRM1HRH3IRAK4KIT | |
| SCHEMBL24577033 | 0.89 | PDGFRA (0.63) | PDGFRACHRM1HRH3IRAK4KIT | |
| SCHEMBL30809586 | 0.88 | PDGFRA (0.55) | PDGFRACHRM1HRH3IRAK4KIT | |
| SCHEMBL30809476 | 0.87 | PDGFRA (0.54) | PDGFRACHRM1HRH3KIT | |
| SCHEMBL30809551 | 0.87 | PDGFRA (0.57) | PDGFRACHRM1HRH3IRAK4KIT | |
| SCHEMBL24576952 | 0.87 | PDGFRA (0.54) | PDGFRACHRM1HRH3KIT | |
| SCHEMBL24576948 | 0.87 | PDGFRA (0.53) | PDGFRACHRM1HRH3KIT | |
| SCHEMBL29759486 | 0.87 | PDGFRA (0.54) | PDGFRACHRM1HRH3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023247596-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | claimed |
| WO-2023247596-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | disclosed |