Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 4/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | WNT1 | P04628 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30809506 | 0.92 | PDGFRA (0.44) | PDGFRACHRM1HRH3JAK1JAK3 | |
| SCHEMBL29759450 | 0.89 | PDGFRA (0.53) | PDGFRACHRM1HRH3GSK3BDYRK1A | |
| SCHEMBL30809540 | 0.88 | PDGFRA (0.42) | PDGFRACHRM1HRH3JAK2CSF1R | |
| SCHEMBL30809509 | 0.87 | PDGFRA (0.42) | PDGFRACHRM1HRH3JAK1JAK3 | |
| SCHEMBL24577428 | 0.87 | PDGFRA (0.46) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL30809445 | 0.86 | PDGFRA (0.43) | PDGFRACHRM1HRH3JAK1JAK3 | |
| SCHEMBL29760161 | 0.86 | PDGFRA (0.46) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL29760148 | 0.85 | PDGFRA (0.45) | PDGFRACHRM1HRH3JAK1JAK3 | |
| SCHEMBL24577404 | 0.85 | PDGFRA (0.45) | PDGFRACHRM1HRH3JAK1JAK3 | |
| SCHEMBL24577744 | 0.85 | PDGFRA (0.44) | PDGFRACHRM1HRH3JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023247596-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | claimed |
| WO-2023247596-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | disclosed |