Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 4/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | GPR6 | P46095 | 12/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30809453 | 0.99 | PDGFRA (0.52) | PDGFRACHRM1HRH3GPR6JAK2 | |
| SCHEMBL30809517 | 0.93 | PDGFRA (0.60) | PDGFRACHRM1HRH3GPR6JAK2 | |
| SCHEMBL24576952 | 0.93 | PDGFRA (0.54) | PDGFRACHRM1HRH3JAK2 | |
| SCHEMBL29759486 | 0.93 | PDGFRA (0.54) | PDGFRACHRM1HRH3JAK2 | |
| SCHEMBL30809499 | 0.91 | PDGFRA (0.54) | PDGFRACHRM1HRH3JAK2IRAK4 | |
| SCHEMBL24578923 | 0.90 | PDGFRA (0.51) | PDGFRACHRM1HRH3JAK2 | |
| SCHEMBL29759965 | 0.90 | PDGFRA (0.51) | PDGFRACHRM1HRH3JAK2 | |
| SCHEMBL30809520 | 0.89 | PDGFRA (0.51) | PDGFRACHRM1HRH3GPR6IRAK4 | |
| SCHEMBL24578922 | 0.88 | PDGFRA (0.53) | PDGFRACHRM1HRH3JAK2IRAK4 | |
| SCHEMBL29760085 | 0.88 | PDGFRA (0.53) | PDGFRACHRM1HRH3JAK2IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023247596-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | claimed |