Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | WRN | Q14191 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MIF | P14174 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 4/20 | 0.35 |
| ▸ | CA12 | O43570 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19145702 | 1.00 | CDK5 (0.37) | CDK5CDK5R1KDM4ENPC1ALDH1A1 | |
| SCHEMBL20657730 | 1.00 | CDK5 (0.37) | CDK5CDK5R1KDM4ENPC1ALDH1A1 | |
| SCHEMBL19127041 | 1.00 | CDK5 (0.37) | CDK5CDK5R1KDM4ENPC1ALDH1A1 | |
| SCHEMBL19127481 | 0.90 | IDH1 (0.38) | CDK5CDK5R1KDM4ENPC1ALDH1A1 | |
| SCHEMBL20676085 | 0.90 | IDH1 (0.38) | CDK5CDK5R1KDM4ENPC1ALDH1A1 | |
| SCHEMBL19126806 | 0.88 | HRH3 (0.40) | CDK5CDK5R1KDM4ENPC1ALDH1A1 | |
| SCHEMBL22075786 | 0.87 | HRH3 (0.37) | CDK5CDK5R1KDM4ENPC1ALDH1A1 | |
| SCHEMBL20676101 | 0.87 | HRH3 (0.37) | CDK5CDK5R1KDM4ENPC1ALDH1A1 | |
| SCHEMBL19126757 | 0.87 | HRH3 (0.37) | CDK5CDK5R1KDM4ENPC1ALDH1A1 | |
| SCHEMBL19126430 | 0.87 | HRH3 (0.42) | CDK5CDK5R1KDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11939314-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2024-03-26 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11939314-B2 | Quinolin-2-one derivatives | KIT, CDK2, CDK1 | CDK5 243/4885CDK5R1 269/4885KDM4E 460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.