⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7874498 | 0.82 | — | — | |
| SCHEMBL16808726 | 0.82 | — | — | |
| SCHEMBL11652702 | 0.81 | TSHR (0.34) | — | |
| SCHEMBL30902191 | 0.81 | TSHR (0.34) | — | |
| SCHEMBL11652697 | 0.81 | TSHR (0.34) | — | |
| Hydrochloric Acid SCHEMBL31249825 | 0.80 | GRIN2D (0.36) | — | |
| SCHEMBL11194617 | 0.80 | — | — | |
| SCHEMBL1218428 | 0.79 | — | — | |
| SCHEMBL27773901 | 0.78 | — | — | |
| SCHEMBL17866516 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 109 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-B1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-01 | — | — | EP | claimed |
| US-7196110-B2 | N-substituted tricyclic 3-aminopyrazoles as inhibitors for the treatment of cell proliferative disorders | JANSSEN PHAMACEUTICA N.V. (BE) | 2007-03-27 | — | — | US | claimed |
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | claimed |
| US-20040082639-A1 | N-substituted tricyclic 3-aminopyrazoles as inhibitors for the treatment of cell proliferative disorders | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-04-29 | — | — | US | claimed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | claimed |
| US-4873362-A | REACTING AN ACYLOXYACETALDEHYDE WITH AN ALDEHYDE USING AN AMINE AND ACID CATALYST SYSTEM | BASF AKTIENGESELLSCHAFT (DE) | 1989-10-10 | — | — | US | claimed |
| EP-3538539-B1 | STEROIDS AND PROTEIN-CONJUGATES THEREOF | REGENERON PHARMA (US) | 2025-08-27 | — | — | EP | disclosed |
| CN-114423752-B | Non-hygroscopic crystalline salts of pyrazole compounds, pharmaceutical compositions and uses thereof | 耶路撒冷希伯来大学伊萨姆研究发展公司 | 2025-06-24 | — | — | CN | disclosed |
| US-12092648-B2 | Detection of glucuronidated and 3-bromotyrosine | THE CLEVELAND CLINIC FOUNDATION (US) | 2024-09-17 | — | — | US | disclosed |
| CN-117916215-A | Indene compound, pharmaceutical composition thereof and therapeutic application thereof | 藤济(厦门)生物医药科技有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-116472034-A | Indene compound, pharmaceutical composition thereof and therapeutic application thereof | 藤济(厦门)生物医药科技有限公司 | 2023-07-21 | — | — | CN | disclosed |
| CN-115916154-A | Osmotic dosage forms comprising deutetrabenazine and methods of use thereof | 奥斯佩克斯医药公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-114989140-A | Benzimidazole derivatives as ERBB tyrosine kinase inhibitors for the treatment of cancer | 卡佩拉医疗公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-1331580-A | Conversion of liquid-filled gelatin capsules into controlled release systems with multiple coatings | ALZA CORP (US) | 2002-01-16 | — | — | CN | disclosed |
| CN-1325301-A | Controlled delivery of active agents | ALZA CORP (US) | 2001-12-05 | — | — | CN | disclosed |
| US-4873362-A | REACTING AN ACYLOXYACETALDEHYDE WITH AN ALDEHYDE USING AN AMINE AND ACID CATALYST SYSTEM | BASF AKTIENGESELLSCHAFT (DE) | 1989-10-10 | — | — | US | disclosed |
| EP-0273314-A2 | Process for the preparation of acyloxyacetaldehydes | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-07-06 | — | — | EP | disclosed |
| US-4331728-A | Laminate made of a cellulose acetate layer and an elastomeric material layer | ALZA CORPORATION (US) | 1982-05-25 | — | — | US | disclosed |
| US-4203439-A | Osmotic system with volume amplifier for increasing amount of agent delivered therefrom | ALZA CORPORATION (US) | 1980-05-20 | — | — | US | disclosed |
| US-4036228-A | Osmotic dispenser with gas generating means | ALZA CORPORATION (US) | 1977-07-19 | — | — | US | disclosed |